diff --git a/DIET.md b/DIET.md
index c872d2b..97dab32 100644
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+++ b/DIET.md
@@ -176,15 +176,27 @@ The high smoke point of refined avocado oil is often cited as its main advantage
 
 #### Unique Bioactive Compounds
 
-**Mannoheptulose — the seven-carbon sugar:**
+**Mannoheptulose — the seven-carbon sugar (framework-cautionary, not framework-positive):**
 
-Mannoheptulose is a rare seven-carbon ketose found in significant amounts in unripe avocados (~2-4 g/100g in green fruit, declining to <0.5 g/100g in fully ripe fruit). Mechanism:
-- **Hexokinase inhibitor** — competitive inhibitor of the enzyme that catalyses the first irreversible step of glycolysis (glucose → glucose-6-phosphate)
-- **Caloric restriction mimetic effect** — by partially blocking glycolytic flux, mannoheptulose mimics some metabolic features of caloric restriction (reduced AMPK activation threshold, increased insulin sensitivity in some models)
-- **Anti-inflammatory in adipose tissue** — Roth et al. (2009) showed mannoheptulose reduced adipose tissue inflammation and improved insulin sensitivity in animal models
-- **Has been studied as a longevity-promoting supplement** — limited human data; predominantly animal studies
+Mannoheptulose is a rare seven-carbon ketose found in significant amounts in unripe avocados (~2-4 g/100g in green fruit, declining to <0.5 g/100g in fully ripe fruit). Mechanism and framework re-evaluation:
 
-**Practical relevance:** Most consumed avocados are fully ripe (mannoheptulose substantially depleted). Eating slightly underripe avocados delivers more mannoheptulose but at the cost of texture and palatability. The compound is not present in commercial avocado oil (extracted from ripe fruit). Magnitude of effect at dietary doses is unclear.
+- **Hexokinase inhibitor** — competitive inhibitor of the enzyme that catalyses the first irreversible step of glycolysis (glucose → glucose-6-phosphate). This is the gateway enzyme that commits glucose to oxidation; inhibiting it reduces glucose flux through glycolysis.
+- **"Caloric restriction mimetic"** — popular framing in the longevity supplement literature; by partially blocking glycolytic flux, mannoheptulose reproduces some metabolic features of caloric restriction (lower glycolytic ATP, lower insulin signalling, reduced postprandial glucose excursion)
+- **Anti-inflammatory in adipose tissue (animal models)** — Roth et al. (2009) showed mannoheptulose reduced adipose tissue inflammation and improved insulin sensitivity in obese animal models
+- **Marketed as a longevity-promoting supplement** — limited human data; predominantly animal studies in metabolically dysfunctional models
+
+**Why this is framework-cautionary, not framework-positive:** The mechanism is in direct opposition to the bioenergetic framework's central premise. The framework treats glucose oxidation as the preferred fuel pathway (RQ 1.0, lowest FADH2:NADH ratio, least reverse-electron-transport-mediated ROS), supports thyroid-driven metabolic rate, and is explicitly skeptical of pharmaceutical glucose-suppression strategies (metformin — Section 4.2 SUPPLEMENTS.md; rapamycin; high-dose berberine; acarbose). Hexokinase inhibition mechanistically belongs in the same category as these: it suppresses glucose disposal, forces fat oxidation via the Randle cycle, and reproduces the metabolic profile of caloric restriction — which the framework views as anti-thyroid, pro-cortisol, and metabolic-rate-suppressing rather than as protective.
+
+The "CR mimetic = good" narrative is the conventional longevity framing, not the framework's framing. The framework's view of caloric restriction's longevity benefit (where it exists) attributes it primarily to *PUFA depletion* (less linoleic acid in tissues = less cardiolipin peroxidation), not to energy restriction per se. By this reading, the protective signal of CR comes from eating fewer seed oils for longer, not from reduced glycolytic flux.
+
+**Why dietary mannoheptulose from avocado is nonetheless not a real concern:** The pharmacologically active doses in animal studies are 200-400 mg/kg/day — equivalent to ~15-30 g/day in humans. A medium ripe avocado delivers <600 mg of mannoheptulose, with the compound largely depleted by ripeness; commercial avocado oil contains essentially none. Typical avocado consumption delivers 25-50x less than the threshold dose for measurable hexokinase inhibition. The compound is biochemically inert at dietary doses from ripe fruit.
+
+**Framework-contraindicated patterns:**
+- Eating slightly-underripe avocados specifically to maximise mannoheptulose intake
+- Mannoheptulose supplements (sold as longevity products) — these deliver pharmacological doses with the mechanistic problems described above
+- Combining hexokinase-inhibiting strategies (mannoheptulose, metformin, prolonged fasting, low-carb diet) — additively suppresses glucose oxidation and downregulates thyroid output
+
+**Practical relevance:** Eat avocados ripe for normal flavour and texture. The mannoheptulose story is a marketing claim, not a framework-aligned reason to consume avocados. The other components (oleic acid, palmitoleic acid, potassium, lutein/zeaxanthin, B5/folate/copper) are the actual reasons avocado is a moderate-positive food.
 
 **Avocatin B — the mitochondrial fatty acid oxidation inhibitor:**
 
@@ -318,7 +330,7 @@ These are not bioenergetic considerations but are relevant if values around sust
 - **Palmitoleic acid content** (~6%): meaningful lipokine contribution at typical serving sizes (1.4g per medium fruit)
 - **PUFA load** (~12% of fat, ~2.6g LA per medium fruit): the binding constraint. Daily avocado consumption contributes one-third to one-half of a framework-aligned LA budget.
 - **Micronutrient density**: highest fruit potassium, meaningful folate/B5/B6/copper/vitamin K1, lutein/zeaxanthin for eye health
-- **Mannoheptulose** (in less-ripe fruit): caloric restriction mimetic potential; modest dietary effect
+- **Mannoheptulose** (in less-ripe fruit): hexokinase inhibitor; framework-cautionary mechanism (suppresses glucose oxidation, mimics CR), but dietary doses from ripe avocado are too low to matter. Not a reason to eat avocado; not a reason to avoid it.
 - **Antinutrient profile**: clean (low oxalate, low phytate, no heat-stable lectins)
 - **Glucose handling**: zero glycemic load, mannoheptulose hexokinase inhibition
 - **Avocado oil category**: complicated by 80%+ adulteration rates in commercial products; verified-pure brands only