2 Commits

Author	SHA1	Message	Date
claude	320cbe4ef2	Deep dive: Pinealon (PEPTIDES.md Section 4.3, Tier 4 — Avoid) — replaces previously lumped mention within Khavinson section with full ~219-line analysis. Discovery: Khavinson group St Petersburg, Glu-Asp-Arg tripeptide as cytogen subset. Proposed Khavinson mechanism (site-directed DNA binding to promoter regions, cell-penetration, transcription factor mimicry, organ-specific gene regulation). Information-theoretic objection as central critique: 3-mer = ~13 bits sequence info vs ~31.5 bits needed for unique site in 3 Gb genome — gap is intrinsic. Three additional convergent biophysics objections: serum peptidase kinetics, absent CPP structural motifs, no ITC/SPR confirmation. Animal evidence covered (Khavinson rodent studies on cognition/ischemia/aging). Human evidence gap (only small unblinded Russian trials). Twitter/social media promotion concern noted honestly. Sourcing concerns (Russian vendors, unverifiable purity). Safety profile (limited Khavinson tox only). Genotype interactions (APOE ε4, DIO2 het, CLOCK CC). Evidence summary table 8 claims. 14 references. Framework alignment: Tier 4 on mechanism implausibility AS CLAIMED + evidence quality grounds. Not claiming biologically inert — door left open for downstream effect via free amino acids or NO-substrate Arg. §4.2 Khavinson reframed as broader methodological critique. GLP-1 cross-ref bumped 4.3 → 4.4. File 734 → 963 lines.	2026-05-24 11:29:47 +08:00
claude	c7e0428468	Create PEPTIDES.md — new sibling document to SUPPLEMENTS.md covering therapeutic peptides through the bioenergetic longevity framework lens. 734 lines, 22 peptide entries plus framework intro. Tier structure: Tier 1 Strongly Aligned (MOTS-c, SS-31/Elamipretide, Humanin, Thymosin α-1), Tier 2 Aligned Context-Dependent (BPC-157, TB-500, GHK-Cu, PDA, LL-37, Selank, Semax, DSIP, Thymalin), Tier 3 Mixed/Complicated (Tesamorelin, Sermorelin, CJC-1295 with/without DAC, Ipamorelin, Hexarelin, MK-677, Cerebrolysin, PT-141, Kisspeptin-10, Melanotan I), Tier 4 Avoid (Melanotan II, Khavinson school bioregulators incl Epitalon, GLP-1 cross-ref to SUPPLEMENTS 4.7). BPC-157 full deep dive (~218 lines): Sikiric Zagreb origin, GEPPPGKPADDAGLV pentadecapeptide, oral vs SC bioavailability controversy, 6-mechanism breakdown with ASCII diagram (NO/eNOS, VEGF, GHR upregulation, FAK-paxillin, brain-gut, monoaminergic), 15+ rodent indications, explicit human-RCT-gap flag, VEGF cancer concern analysis, dosing, genotype interactions, stack interactions, sourcing concerns, 18 key references, evidence summary table. Framework intro covers bioenergetic application to peptides, route/bioavailability primer, research-chemical sourcing problem, cancer concerns for growth-promoting peptides. Framework consistency calls: GH-axis peptides Tier 3 (chronic IGF-1 → mTOR override), MK-677 flagged near Tier 4 (24h sustained vs pulsatile), CJC-1295 with-DAC vs without-DAC split, Melanotan I/II split, Khavinson school Tier 4 with honest evidence framing. Stubs for all non-BPC-157 entries ready for future deep dives.	2026-05-24 11:14:31 +08:00