claude
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c7e0428468
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Create PEPTIDES.md — new sibling document to SUPPLEMENTS.md covering therapeutic peptides through the bioenergetic longevity framework lens. 734 lines, 22 peptide entries plus framework intro. Tier structure: Tier 1 Strongly Aligned (MOTS-c, SS-31/Elamipretide, Humanin, Thymosin α-1), Tier 2 Aligned Context-Dependent (BPC-157, TB-500, GHK-Cu, PDA, LL-37, Selank, Semax, DSIP, Thymalin), Tier 3 Mixed/Complicated (Tesamorelin, Sermorelin, CJC-1295 with/without DAC, Ipamorelin, Hexarelin, MK-677, Cerebrolysin, PT-141, Kisspeptin-10, Melanotan I), Tier 4 Avoid (Melanotan II, Khavinson school bioregulators incl Epitalon, GLP-1 cross-ref to SUPPLEMENTS 4.7). BPC-157 full deep dive (~218 lines): Sikiric Zagreb origin, GEPPPGKPADDAGLV pentadecapeptide, oral vs SC bioavailability controversy, 6-mechanism breakdown with ASCII diagram (NO/eNOS, VEGF, GHR upregulation, FAK-paxillin, brain-gut, monoaminergic), 15+ rodent indications, explicit human-RCT-gap flag, VEGF cancer concern analysis, dosing, genotype interactions, stack interactions, sourcing concerns, 18 key references, evidence summary table. Framework intro covers bioenergetic application to peptides, route/bioavailability primer, research-chemical sourcing problem, cancer concerns for growth-promoting peptides. Framework consistency calls: GH-axis peptides Tier 3 (chronic IGF-1 → mTOR override), MK-677 flagged near Tier 4 (24h sustained vs pulsatile), CJC-1295 with-DAC vs without-DAC split, Melanotan I/II split, Khavinson school Tier 4 with honest evidence framing. Stubs for all non-BPC-157 entries ready for future deep dives.
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2026-05-24 11:14:31 +08:00 |
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