claude 6d88496404 Restore lost Tier 4 + Appendix A content (1231 sanitized lines). The original commit pushing SUPPLEMENTS.md to this repo was already missing this content (lost in upstream commit 1afbfe5 which dropped the file from 20,238 → 19,413 lines while adding the Alpha-Lipoic Acid section — the Tier 4 header was preserved but everything below it was truncated). Restored from upstream peak commit 264505c with personal references sanitized: Section 4.1 Statins (stub), Section 4.2 Metformin (full deep dive: Complex I/ND3 inhibition, Konopka 2019 exercise blunting, Aroda 2016 B12 depletion, mGPD inhibition, GI serotonin, TSH suppression, TAME framework interpretation, AMPK alternatives table), Section 4.3 High-Dose Antioxidants (stub), Section 4.4 Rapamycin (stub), Section 4.5 Fluoride (stub), Section 4.6 Iron — Dietary Yes Supplemental No (~254 lines), Section 4.7 GLP-1 Receptor Agonists (~420 lines: STEP/SELECT/SUSTAIN/FLOW trials, lean mass loss, MTC black box, GI pathology, metabolic suppression, TCF7L2 TT pharmacogenomic counterargument), Appendix A Excipients & Additives. Sanitized: 'this user' → 'someone with this profile', 'BMI 19.4 / 58 kg' → 'lean adult / low BMI', 'the user's X genotype' → 'X genotype (in carriers)', 36-year-old male → adult. File now 20,983 lines.

2026-05-10 09:08:04 +08:00

ALUMINUM_DETOXIFICATION.md

Add ALUMINUM DETOXIFICATION

2026-05-02 15:30:26 +08:00

COMPUTATIONAL_BIOLOGY.md

Add COMPUTATIONAL BIOLOGY

2026-05-02 15:30:21 +08:00

DIET.md

Correct framework framing of mannoheptulose in avocado section. Original framing pitched mannoheptulose as a longevity-positive bonus via 'CR mimetic' effect — this is mechanistically inconsistent with the framework's actual stance. Hexokinase inhibition suppresses glucose oxidation (the framework's preferred fuel pathway), forces fat oxidation via Randle cycle, mimics caloric restriction (which the framework views as anti-thyroid, pro-cortisol, metabolic-rate-suppressing). Mannoheptulose mechanistically belongs in the same category as metformin, rapamycin, acarbose, berberine — drugs the framework is skeptical of. The CR longevity benefit (where it exists) more plausibly attributes to PUFA depletion than to glucose restriction. Re-framed as 'framework-cautionary, not framework-positive', noted that dietary dose from ripe avocado (~600mg) is 25-50x below pharmacological threshold (15-30g human equivalent) so practically inert. Flagged as framework-contraindicated: eating unripe avocados for mannoheptulose, mannoheptulose supplements, stacking with other glucose-suppressing strategies. Updated framework alignment summary line accordingly.

2026-05-06 11:45:22 +08:00

EXPOSURES.md

Add exposures and fat loss quick start

2026-05-02 15:30:05 +08:00

FAT_LOSS_GUIDE.md

Add FAT LOSS GUIDE

2026-05-02 15:30:16 +08:00

FAT_LOSS_QUICK_START.md

Add exposures and fat loss quick start

2026-05-02 15:30:05 +08:00

LONGEVITY_GUIDELINES.md

Add LONGEVITY GUIDELINES

2026-05-02 15:30:24 +08:00

MERCURY_DETOXIFICATION.md

Add MERCURY DETOXIFICATION

2026-05-02 15:30:25 +08:00

METABOLISM_AND_AGING.md

Add METABOLISM AND AGING

2026-05-02 15:30:18 +08:00

METABOLISM_AND_ALZHEIMERS.md

Add METABOLISM AND ALZHEIMERS

2026-05-02 15:30:20 +08:00

METABOLISM_AND_CANCER.md

Add METABOLISM AND CANCER

2026-05-02 15:30:19 +08:00

MULTI_LAYER_BIOLOGICAL_FOUNDATION_MODEL.md

Add MULTI LAYER BIOLOGICAL FOUNDATION MODEL

2026-05-02 15:30:22 +08:00

PLAN.md

Add PLAN

2026-05-02 15:30:27 +08:00

SUPPLEMENTS.md

Restore lost Tier 4 + Appendix A content (1231 sanitized lines). The original commit pushing SUPPLEMENTS.md to this repo was already missing this content (lost in upstream commit 1afbfe5 which dropped the file from 20,238 → 19,413 lines while adding the Alpha-Lipoic Acid section — the Tier 4 header was preserved but everything below it was truncated). Restored from upstream peak commit 264505c with personal references sanitized: Section 4.1 Statins (stub), Section 4.2 Metformin (full deep dive: Complex I/ND3 inhibition, Konopka 2019 exercise blunting, Aroda 2016 B12 depletion, mGPD inhibition, GI serotonin, TSH suppression, TAME framework interpretation, AMPK alternatives table), Section 4.3 High-Dose Antioxidants (stub), Section 4.4 Rapamycin (stub), Section 4.5 Fluoride (stub), Section 4.6 Iron — Dietary Yes Supplemental No (~254 lines), Section 4.7 GLP-1 Receptor Agonists (~420 lines: STEP/SELECT/SUSTAIN/FLOW trials, lean mass loss, MTC black box, GI pathology, metabolic suppression, TCF7L2 TT pharmacogenomic counterargument), Appendix A Excipients & Additives. Sanitized: 'this user' → 'someone with this profile', 'BMI 19.4 / 58 kg' → 'lean adult / low BMI', 'the user's X genotype' → 'X genotype (in carriers)', 36-year-old male → adult. File now 20,983 lines.

2026-05-10 09:08:04 +08:00

THERAPIES.md

Add therapeutic modalities (PBM, pranayama, yoga, HBOT, fasting)

2026-05-02 15:30:41 +08:00

Description

No description provided

3.7 MiB

Languages

Markdown 100%